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TDM35—a new monoclonal antibody to the XH1 cervical carcinoma cell line. Characterization and immunoperoxidase localization in benign and malignant tissues
Author(s) -
Chana Treena,
Han Xin,
Dagg Belinda,
Lawrie Andrew S.,
Gooding Roger P.,
Eustace Damian L. S.,
Fletcher Christopher D. M.,
Heyderman Eadie
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711670408
Subject(s) - immunoperoxidase , monoclonal antibody , cervical carcinoma , pathology , medicine , carcinoma , antibody , biology , cervical cancer , immunology , cancer
The murine monoclonal IgG1 kappa antibody TDM35 was raised against the cervical carcinoma cell line XH1. The antibody recognizes 18.5–66 kDa NCA‐like glycoproteins and immunostains a variety of formalin‐fixed, paraffin‐embedded normal, benign, and malignant tissues. It is of value in the diagnosis of carcinoma of the exocrine pancreas and it identifies foci of squamous and glandular differentiation in other tumours. TDM35 should form a useful addition to a panel of antibodies for the evaluation of epithelial lesions.