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Seminal vesicle amyloid: The first example of exocrine cell origin of an amyloid fibril precursor
Author(s) -
Cornwell Gibbons G.,
Westermark Gunilla T.,
Pitkanen Peter,
Westermark Per
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711670307
Subject(s) - amyloid fibril , amyloid (mycology) , fibril , vesicle , chemistry , amyloid β , pathology , biochemistry , medicine , disease , membrane
Amyloid fibrils have been extracted from seminal vesicles, and a dominant 14 kD amyloid fibril protein has been identified. An antiserum to this protein reacted both with amyloid and with epithelial cells in some normal seminal vesicles. These reactions were blocked with seminal vesicle secretion and seminal vesicle amyloid fibril protein, but not by degraded amyloid fibrils or fibril protein from other types of amyloid. It is concluded that seminal vesicle amyloid is derived from secretory proteins of the seminal vesicles. As such, it is the first amyloid described which appears to be the product of an exocrine secretory cell.