Premium
Image analysis in the discrimination of verrucous carcinoma and squamous papilloma
Author(s) -
Cooper John R.,
Hellquist Henrik B.,
Michaels Leslie
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711660410
Subject(s) - verrucous carcinoma , basal cell , papilloma , pathology , medicine , carcinoma , human papilloma virus , dermatology , cancer , cervical cancer
Abstract Verrucous carcinoma is a differentiated variant of squamous cell carcinoma and may present diagnostic difficulties as it may be erroneously diagnosed as squamous papilloma. In this study, the sizes of the intermediate cells in thes two conditions were measured by means of morphometric analysis. Biopsies from 28 patients with verrucous carcinoma, 25 patients with squamous papilloma, and ten squamous cell carcinomas were analysed. A significant difference was shown ( P < 0.001) by an uncorrelated t ‐test between verrucous carcinoma and squamous papilloma. The former had a mean cell area of 373 μm 2 and the latter 184 μm 2 . Squamous cell carcinomas differed from the other two neoplasms by thier large range of cell areas both within and between cases. Thus, image analysis can be of diagnostic help in cases where no firm initial histopathological diagnosis can be obtained. The diagnosis should be made on morphological grounds, but a mean cell area greater than 300 μm 2 supports a diagnosis of verrucous carcinoma whereas an area less than 250 μm 2 supports a diagnosis of squamous papilloma.