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Lymphocytes in pseudomembranes of late prosthetic joint failure
Author(s) -
Salter D. M.,
Krajewski A. S.,
Robertson S.
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711660309
Subject(s) - histiocyte , rheumatoid arthritis , pathology , medicine , aseptic processing , giant cell , immunology , surgery
Abstract The pseudomembrane formed in association with late aseptic prosthesis failure contains a mixed giant cell and histiocytic infiltrate with variable numbers of lymphocytes. Immunolabelling with a panel of antibodies on paraffin sections was undertaken to define the nature of the lymphoid infiltrate in 19 cases. In all cases, the predominant lymphoid cell was a memory (CD45RO +, CD45RA‐) T‐cell. B‐cells were rare. Tissue from patients with rheumatoid arthritis (RA) contained greater numbers of T‐cells when compared with patients with osteoarthritis (OA), suggesting that the intensity of the lymphoid infiltrates reflects the underlying joint disease rather than necessarily being part of a hypersensitivity response to wear debris.