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A comparison of proliferating cell nuclear antigen (PCNA) immunostaining, nucleolar organizer region (AGNOR) staining, and histological grading in gastrointestinal stromal tumours
Author(s) -
Yu Carmen C.W.,
Fletcher Christopher D. M.,
Newman Paul L.,
Goodlad John R.,
Burton Julia C.,
Levison David A.
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711660210
Subject(s) - proliferating cell nuclear antigen , immunostaining , grading (engineering) , pathology , nucleolus organizer region , biology , stromal cell , staining , immunohistochemistry , medicine , nucleolus , ecology , biochemistry , cytoplasm
Gastrointestinal stromal tumours are lesions in which it is difficult to predict clinical outcome from the histological appearances. Sixty cases were studied using three different methods of assessing aspects of cellular proliferation; these were (i) immunostaining for proliferating cell nuclear antigen (PCNA), (ii) interphase nucleolar organizer region staining (AgNORs). and (iii) a histological grading system based on mitotic counts. Both PCNA immunostaining and AgNOR counts were found to correlate well with histological grading and all three methods independently showed good correlations with survival. This suggests that these proliferation‐associated markers may be used as additional features to support histological grading in this relatively uncommon group of tumours.