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Video image analysis of AgNOR distribution in the normal and adenomatous colorectum
Author(s) -
Weeks Sandy C.,
Beroukas Dimitra,
Jarvis Lynn R.,
Whitehead Richard
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711660209
Subject(s) - rectum , dysplasia , crypt , adenomatous polyps , pathology , gastroenterology , adenoma , nucleolus organizer region , significant difference , medicine , biology , colorectal cancer , colonoscopy , nucleus , cancer , nucleolus , psychiatry
The nucleolar organizer regions (AgNORs) have been studied by video image analysis in the normal colorectum and in adenomas arising there. Total AgNOR area was measured in conjunction with the total area of nuclei and expressed as a ratio. AgNORs are found to predominate in the proliferative regions of the normal mucosal crypt, and the ratio of AgNOR to nuclear area proved significantly greater in the normal colon than in the rectum and far greater in colorectal adenomas. Further, there is a significant difference between the ration in tubular as opposed to villous patterns of adenomatous growth in the colon but not in the rectum. When classified according to their degree of dysplasia, adenomas in the rectum exhibit a significantly higher ratio of AgNOR to nuclear area as the degree of dysplasia increases in severity. This correlation is not shown in the colon.