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CD23 expression in non‐Hodgkin lymphoma: Immunohistochemical demonstration using the antibody BU38 on paraffin sections
Author(s) -
Murray Paul G.,
Janmohamed Riaz M. I.,
Crocker John
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711650207
Subject(s) - cd23 , lymphoma , immunohistochemistry , antibody , follicular lymphoma , pathology , follicular dendritic cells , antigen , lymphocyte , immunoglobulin e , medicine , immunology , biology , immune system , t cell , antigen presenting cell
The leucocyte antigen CD23 is upregulated in the early stages of B‐cell activation by Interleukin‐4 (IL‐4), and functions as an IgE receptor and lymphocyte growth factor. We have studied the expression of CD23 in 68 cases of non‐Hodgkin lymphoma (NHL) using the antibody BU38. This new antibody has the great advantage of being applicable to routinely‐processed paraffin sections. CD23 was expressed in tumour cells in 27 out of 36 cases of low grade NHL and 3 out of 32 cases of high grade NHL. Follicular dendritic cells were strongly positive and were seen in follicular lymphomas. Macrophages were also positive and were numerous in high grade lesions.