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Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells
Author(s) -
Foulis A. K.,
McGill M.,
Farquharson M. A.
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711650203
Subject(s) - insulitis , medicine , diabetes mellitus , type 1 diabetes , interferon , interferon gamma , endocrinology , insulin , pathogenesis , macrophage , immunology , cytokine , biology , in vitro , biochemistry
Abstract This study sought to determine, firstly, the relative frequency of lymphocytes and macrophages and, secondly, the percentage of lymphocytes containing interferon‐γ in inflamed islets (insulitis) of patients with type 1 (insulindependent) diabetes. Autopsy pancreases of 12 patients who had died of recent‐onset type 1 diabetes and one prediabetic patient who had died of cardiomyopathy were examined immunohistochemically. In the 87 islets that were studied, the lymphocyte macrophage ratio was 9·7:1 and approximately 40 per cent of the lymphocytes contained interferon‐γ. Interferon‐γ release in the insulitis process may be involved in the pathogensis of type 1 diabetes.