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Cell adhesion and epithelial differentiation
Author(s) -
Fleming Stewart
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711640202
Subject(s) - microbiology and biotechnology , cell adhesion molecule , epithelium , cell adhesion , laminin , basal lamina , adhesion , cadherin , cellular differentiation , biology , integrin , chemistry , cell , extracellular matrix , anatomy , ultrastructure , biochemistry , genetics , gene , organic chemistry
The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion beween cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti‐oncogene plays a regulatory role in renal epithelial differentiation. Tissue modelling and tumour formation are both accompanied by reduced cell adhesion molecule function.