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Grading of superficial antral gastritis: Comparison of cell‐counting and photographic‐based methods
Author(s) -
Collins J. S. A.,
Watt P. C. H.,
Hamilton P. W.,
Sloan J. M.,
Love A. H. G.
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711630311
Subject(s) - grading (engineering) , medicine , mean difference , cell counting , antrum , significant difference , biopsy , nuclear medicine , gastritis , gastroenterology , pathology , stomach , biology , confidence interval , cancer , ecology , cell cycle
A cell‐counting technique and a photographic‐based scoring system for assessing inflammatory cell infiltration were compared for agreement in 275 endoscopic gastric antral biopsies from 55 dyspeptic patients. Each biopsy was independently scored 0–5 for polymorphs and mononuclear cells using both methods, and a mean score was derived for each patient. There was a highly significant correlation between the mean patient scores obtained using each method ( P < 0·001). Agreement statistics showed that the mean score difference (cell‐counting minus photographic score) was negative for polymorphonuclear and mononuclear cells, indicating that the photographic method yielded higher mean patient scores. Scatterplots of difference versus mean by the two methods showed that only 3·6 per cent of scores fell outside ±2 SD of the mean difference. The use of standard photomicrographs to grade superficial antral gastritis therefore provides accurate results, comparable to those obtained by cell counting, yet is a faster and much cheaper technique.