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Nucleolar organizer regions and prognosis in renal cell carcinoma
Author(s) -
Delahunt Brett,
Ribas Jorge L.,
Nancy John N.,
Bethwaite Peter B.
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711630107
Subject(s) - stage (stratigraphy) , nucleolus organizer region , renal cell carcinoma , proportional hazards model , hazard ratio , medicine , survival analysis , carcinoma , log rank test , statistical significance , oncology , biology , pathology , nucleolus , confidence interval , genetics , paleontology , cytoplasm
Abstract The prognostic significance of nucleolar organizer regions (NORs) in renal cell carcinoma (RCC) was evaluated. NORs were quantified in a series of 182 cases of RCC using the silver‐colloid method. The cases were staged according to Robson's method (48 stage I, 26 stage II, 33 stage III, 75 stage IV) and mean NOR numbers for each tumour were correlated with survival over a 5‐year period. Localized tumours (stages I and II) with low NOR numbers had an almost 100 per cent 5‐year survival. Those patients with clinical evidence of metastases at presentation showed a high mortality, although those with low numbers of NORs had a significantly increased disease‐free interval. Statistical analysis using the log rank test indicated NORs to be a significant predictor of survival over the whole series ( P = 0·0001) and within each of Robson's stages ( P = 0·0008 stage I, P = 0·0154 stage II, P = 0·0009 stage III, P = 0·0001 stage IV). Analysis of data using Cox's proportional hazard model showed mean NOR numbers to be independent of stage as a predictor of survival.