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Translocation (11;14): A cytogenetic anomaly associated with B‐cell lymphomas of non‐follicle centre cell lineage
Author(s) -
Vandenberghe Elisabeth,
De WolfPeeters Chris,
Van Den Oord Joost,
Wlodarska Ivonna,
Delabie Jan,
Stul Michel,
Thomas José,
Michaux JeanLouis,
Mecucci Cristina,
Cassiman JeanJacques,
Van Den Berghe Herman
Publication year - 1991
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711630104
Subject(s) - chromosomal translocation , immunophenotyping , lineage (genetic) , lymphoma , biology , pathology , breakpoint , cytogenetics , b cell , cd43 , cancer research , cd20 , immunology , medicine , genetics , flow cytometry , chromosome , antibody , gene
Nine patients with t(11;14) and B non‐Hodgkin's lymphomas composed of small to intermediately sized cells with irregular nuclei are described. Immunophenotyping was performed on seven cases, which were M+, D− with light chain restriction, CD5+, CD10−, and CD20+, suggesting that they were non‐follicle centre cell lymphomas. The translocation (11;14) (in three cases the only cytogenetic anomaly) was associated with rearrangement of bcl‐1 in four of the five cases investigated. Translocation (11;14) has been described in an apparently heterogeneous group of low‐grade lymphoid malignancies which we suggest have a non‐follicle centre cell lineage in common. This translocation may be associated with these lymphomas in the same way that t(14; 18) is associated with follicle centre cell lymphomas.