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The osteoclast, which derives from a haemopoietic stem cell, is not depleted in aplastic anaemia
Author(s) -
Flanagan Adrienne M.
Publication year - 1990
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711620313
Subject(s) - osteoclast , haematopoiesis , megakaryocyte , stem cell , immunology , monocyte , granulocyte , aplastic anemia , biology , bone marrow , population , medicine , microbiology and biotechnology , genetics , in vitro , environmental health
The osteoclast derives from the haemopoietic stem cell but its relationship with the other progeny of the haemopoietic system is unknown. Osteoclast numbers were assessed in patients with aplastic anaemia and were found not to be depleted compared with a control population. This suggests that the osteoclast may develop along a separate lineage which is independent of the colony forming unit granulocyte, erythroid cell, monocyte, and megakaryocyte (CFU GEMM).