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Clinical, biochemical and immunoelectron microscopical evidence of dual hormone production in a mammosomatotroph cell adenoma
Author(s) -
Cameron Stuart,
Allen Ingrid,
Ozo Chukwuemiko,
Kennedy Laurence,
Atkinson Brew,
Hadden David
Publication year - 1990
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711610311
Subject(s) - immunoelectron microscopy , adenoma , pathology , medicine , biology , immunohistochemistry
This paper reports the occurrence of a rare, yet distinct pituitary adenoma which was surgically removed from a 42‐year‐old male with both clinical and biochemical evidence of acromegaly and mild hyperprolactinaemia. The monomorphic adenoma consisted of mature cells which were ultrastructurally indistinguishable from those of a prolactinoma. Electron immunocytochemistry, including a series of double‐labelling techniques using selected colloidal gold particles as markers, indicated the presence of a pituitary adenoma in which the cells were capable of simultaneously producing growth hormone and prolactin and packaging them within the same secretory granule. This is thought to represent a mammosomatotroph cell adenoma.