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Myopathy of internal anal sphincter with polyglucosan inclusions
Author(s) -
Martin J. E.,
Swash M.,
Kamm M. A.,
Mather K.,
Cox E. L.,
Gray A.
Publication year - 1990
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711610308
Subject(s) - internal anal sphincter , anal sphincter , myopathy , constipation , sphincter , anatomy , medicine , pathology , urethral sphincter , external anal sphincter , anal canal , rectum , gastroenterology , surgery , urethra
In two members of an affected family with a hereditary syndrome of proctalgia fugax and constipation, a hypertro‐phied internal anal sphincter was found with histological features suggesting a myopathy of this muscle. In these two patients, and in an unrelated patient with a similar clinical syndrome, smooth muscle fibres of the internal anal sphincter showed numerous vacuoles, many of which contained ovoid inclusion bodies. The structural features and histochemical reactions of the inclusion bodies were consistent with a polyglucosan composition. Histological examination of the internal anal sphincter may reveal smooth muscle abnormalities in functional bowel disorders.