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Morphometric definition and grading of gastric intestinal metaplasia
Author(s) -
Tosi P.,
Filipe M. I.,
Baak J. P. A.,
Luzi P.,
Santopietro R.,
Miracco C.,
Sforza V.,
Megha T.
Publication year - 1990
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711610306
Subject(s) - pathology , metaplasia , intestinal metaplasia , nuclear atypia , biology , grading (engineering) , atypia , population , epithelium , vacuole , dysplasia , anatomy , cytoplasm , medicine , microbiology and biotechnology , immunohistochemistry , ecology , environmental health
Type I and type III intestinal metaplasia in gastric mucosa have been examined using morphometric methods. Tissue (volume per cent gland, lumen, epithelium, goblet cell vacuoles) and nuclear parameters (area, with related standard deviation, and form factors) were used as indicators of gland crowding, nuclear‐cytoplasmic ratio, nuclear atypia, and pleomorphism. In type III intestinal metaplasia, there is significantly (i) greater nuclear pleomorphism, (ii) a higher nuclear‐cytoplasmic ratio, and (iii) smaller and less numerous goblet cell vacuoles in both the upper and the lower parts of the crypts. These two parameters have significantly higher values in the lower than in the upper part of individual crypts. No cell population with large pleomorphic nuclei characterized type III metaplasia, though there was more variation in nuclear size.