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Ultrastructure of the jejunal mucosa in human immunodeficiency virus infection
Author(s) -
Mathan Minnie M.,
Griffin G. E.,
Miller A.,
Batman P.,
Forster S.,
Pinching A.,
Harris W.
Publication year - 1990
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711610206
Subject(s) - ultrastructure , human immunodeficiency virus (hiv) , virology , biology , virus , intestinal mucosa , immunodeficiency , pathology , medicine , immunology , immune system
The ultrastructural changes in the jejunal muscosa of 11 male patients, three with clinical AIDS, five with AIDS related complex‐progressive generalized lymphadenopathy (ARC‐PGL), and three who were only HIV antibody positive, were studied. In the enterocytes, major abnormalities were proliferation of smooth endoplasmic reticulum mitochondrial changes, vacuolization of cells, and fat hold up. In the lamina propria, degeneration of enteric nerve axons and smooth muscle were seen. Microvasculature showed both endothelial cell degeneration and hyperplasia. The presence of tubuloreticular inclusions in endothelial cells paralleled the stage of the disease. Since none of the 11 patients had any opportunistic infection, these changes are likely to be the effect of HIV infection.