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Cellular and humoral immune responses in Campylobacter pylori ‐associated chronic gastritis
Author(s) -
Kazi Javed Iqbal,
Sinniah Raja,
Jaffrey N. A.,
Alam S. M.,
Zaman V.,
Zuberi S. J.,
Kazi A. M.
Publication year - 1989
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711590310
Subject(s) - campylobacter , gastritis , immune system , chronic gastritis , immunology , humoral immunity , medicine , helicobacter pylori , biology , gastroenterology , bacteria , genetics
Gastric cellular and humoral immune responses investigated by immunoperoxidase staining of 53 antral biopsies showed significant differences in Campylobacter pylori ‐associated gastritis as compared with non‐bacterial chronic gastritis and normal controls. IgA, secretory component, and complement C3 coated bacilli were seen in all cases of active chronic gastritis. C3 was always associated with coating by IgA, IgM, or both, which were rarely seen in gastritis without polymorphonuclear neutrophil infiltration. Intraepithelial mononuclear cellular infiltration was seen in 18 of 26 cases of C. pylori‐associated chronic gastritis. The intraepithelial mononuclear cells stained positively for T cells and histiocytes.