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A non‐parametric grading system for intestinal metaplasia: Correlations with gastric tissue enzymes
Author(s) -
Finch P. J.,
Fallowfield M. E.
Publication year - 1989
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711580406
Subject(s) - intestinal metaplasia , grading (engineering) , kappa , metaplasia , pathology , lactic dehydrogenase , gastroenterology , enzyme , medicine , chemistry , biology , stomach , biochemistry , mathematics , ecology , geometry
A novel method for grading intestinal metaplasia, with general applicability, is described. Highly significant agreement was found by kappa analysis both for intra‐observer ( k =0.90) and for inter‐observer ( k =0.85) variation, confirming the reproducibility of the method. The ranks derived by this method were correlated with gastric tissue levels of the enzymes beta‐glucuronidase, lactic dehydrogenase (LDH), and %m‐LDH. A significant ( P <0.05) positive correlation was found between intestinal metaplasia and %m‐LDH, but there was no correlation between intestinal metaplasia and beta‐glucuronidase or LDH.