Premium
Null cell adenomas of the pituitary gland. An immunohistochemical study
Author(s) -
Holm Ruth,
Nesland Jahn M.,
Attramadal Arne,
Halse Johan,
Johannessen Jan V.
Publication year - 1989
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711580307
Subject(s) - immunohistochemistry , null cell , pituitary gland , pathology
Fourteen null cell adenomas of the pituitary gland were examined immunohistochemically with antisera against three general neuroendocrine markers and 22 hormones. All cases showed positive immunostaining for neuron‐specific enolase, ten cases for synaptophysin, and six cases expressed chromogranin immunoreactivity. Hormone immunoreactivity was detected in a few cells in ten of the 14 cases studied and the number of hormones demonstrated in each case was one or two, Thyroid‐stimuating hormone was detected in five of the 14 cases, gastrin in four, β‐endorphin in two, calcitonin gene related peptide in one, prolactin in one, and follicle‐stimulating hormone in one.