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T‐cell antigen receptor beta‐chain variable region families: A study of their distribution in normal and reactive tissues
Author(s) -
Clark David M.,
Boylston Arthur W.
Publication year - 1989
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711580104
Subject(s) - gene , biology , microbiology and biotechnology , antigen , t cell receptor , antibody , receptor , immunology , t cell , genetics , immune system
Abstract The beta chain of the T‐cell antigen receptor is constructed using a variable region gene from one of approximately 20 variable gene families. Antibodies that react with the products of these gene families have been used to demonstrate clonal proliferation of T cells. Here, we describe the expression of two beta‐chain variable region families in normal and reactive lymphoid tissues. In all the tissues studied, expression was scattered throughout the T‐cell areas, without any clustering of expression.