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An analysis of spontaneous and chemotherapy‐associated changes in skeletal osteosarcomas
Author(s) -
Misdorp W.,
Hart G.,
Delemarre J. F. M.,
Voŭcte P. A.,
Van Der Eijken J. W.
Publication year - 1988
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711560206
Subject(s) - chemotherapy , osteosarcoma , medicine , logistic regression , statistical analysis , oncology , pathology , statistics , mathematics
Microscopically assessed changes observed in large sections of osteosarcomas from patients who had undergone pre‐operative chemotherapy (PCT) ( n =22), or no chemotherapy ( n =22), were examined either quantitatively, semi‐quantitatively, or qualitatively. Eight tumour characteristics were associated with the treatment mode by way of a stepwise logistic analysis. Minimal amount of viable tumour tissue (< 10 per cent) and strong fibroblastic proliferation were each proved to be associated with PCT. These two variables in combination indicated a good response to PCT. The discrimination between PCT and non‐PCT patients based on statistical analysis was superior to discrimination based on ‘overall impression’.