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Functional and biosynthetic changes in endothelial cells of vessels in chronically inflamed tissues: Evidence for endothelial control of lymphocyte entry into diseased tissues
Author(s) -
Freemont Anthony J.
Publication year - 1988
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711550308
Subject(s) - lymphocyte , pathology , biology , immunology , endothelial stem cell , endothelium , microbiology and biotechnology , medicine , biochemistry , endocrinology , in vitro
In vitro lymphocyte adhesion to, and selective radiosulphate uptake by, endothelial cells has been demonstrated in chronically inflamed tissues of patients with peptic ulceration, rheumatoid disease, pilonidal sinus, autoimmune thyroiditis, polymyositis, primary biliary cirrhosis, and pyelonephritis. These characteristics have been described previously in endothelial cells functionally specialized for promoting lymphocyte traffic from blood to lymph node parenchyma. It is suggested that these observations indicate that some vessels in inflamed tissues may be, at least in part, responsible for the selective accumulation of lymphocytes within the tissue. Manipulating the development of this type of vessel may offer a novel way of influencing the progress of inflammatory disorders.