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Subacute infantile mountain sickness
Author(s) -
Sui G. J.,
Liu Y. H.,
Cheng X. S.,
Anand I. S.,
Harris E.,
Harris P.,
Heath D.
Publication year - 1988
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711550213
Subject(s) - pulmonary trunk , muscle hypertrophy , medicine , right ventricular hypertrophy , ventricle , disease , effects of high altitude on humans , cardiology , trunk , pulmonary disease , myocardial hypertrophy , anatomy , pulmonary artery , biology , ecology
A description is given of a disease of infants occurring in Lhasa, Tibet at an altitude of 3600m. Typically it affects infants who have been born at low altitude and subsequently brought to reside in Lhasa, and it is usually fatal within a few weeks or months. There is extreme medial hypertrophy of muscular pulmonary arteries and muscularization of pulmonary arterioles, together with dilatation of the pulmonary trunk and massive hypertrophy and dilatation of the right ventricle. The disease is distinct from acute or chronic mountain sickness and appears to be the human counterpart of ‘brisket disease’ in cattle.