Premium
Monoclonal S‐100 immunocytochemistry of pigmented naevi with tactile‐like corpuscles
Author(s) -
Suzuki Toshimitsu,
Ajioka Yoichi,
Kogure Shoji
Publication year - 1988
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711550208
Subject(s) - immunocytochemistry , monoclonal antibody , immunohistochemistry , pathology , polyclonal antibodies , biology , antibody , protein subunit , monoclonal , anatomy , medicine , immunology , biochemistry , gene
We examined 12 cases of pigmented naevi with tactile‐like corpuscles by immunohistochemistry using polyclonal and monoclonal antibodies against S‐100 protein. Naevus cells, the tactile‐like corpuscles, and the attached lamellae and fibroblastic cells gave a strong reaction with S‐100 protein and the β‐subunit antibodies. The same cells gave only a weak reaction with the a ‐subunit antibody with the exception of about 4 per cent of corpuscles and 1–1.5 per cent of naevus cells, whether pigmented or not, which gave a strong reaction with this antibody. These results suggest that the non‐pigmented naevus cells and the constituent cells of the corpuscles are closely related and the latter might derive from the former by organoid differentiation.