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Endodermal sinus (yolk sac) tumour of the liver. A case report and review of the literature
Author(s) -
Narita Takeo,
Moriyama Yuzo,
Ito Yasuo
Publication year - 1988
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711550108
Subject(s) - yolk sac , endodermal sinus tumor , pathology , sinus (botany) , medicine , anatomy , biology , embryo , microbiology and biotechnology , zoology , genus
A primary endodermal sinus tumour of the liver which developed in a 27‐year‐old woman is reported. The dimensions of the tumour were 11 × 11 × 9·5 cm. Most parts were friable, haemorrhagic, and necrotic. No metastasis was found, but one part of the tumour was invading the diaphragm directly. Histologically, the tumour had mainly a reticular pattern, and partly a solid pattern, and was characterized by the presence of Schiller–Duval bodies and intra‐and extracellular hyaline globules. A small part of the tumour showed a polyvesicular vitelline pattern and glandular structures with enteric differentiation. Serum alpha‐fetoprotein was very high (28 500 ng/ml), but carcinoembryonic antigen was within the normal range. Immunohistochemically, most of the tumour cells contained alpha‐fetoprotein and alpha‐1‐antitrypsin. Carcinoembryonic antigen and glutathione S‐transferase, which was recently proved to be a useful marker for colonic carcinoma, were detected only in the glandular part. Four previously reported cases of primary endodermal sinus tumour of the liver are reviewed.