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Demonstration of human papillomavirus types 6 and 11 in juvenile laryngeal papillomatosis by in‐situ DNA hybridization
Author(s) -
Terry R. M.,
Lewis F. A.,
Griffiths S.,
Wells M.,
Bird C. C.
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711530308
Subject(s) - in situ hybridization , human papillomavirus , papillomatosis , in situ , biology , pathology , papilloma , dna–dna hybridization , epithelium , dna , microbiology and biotechnology , medicine , chemistry , gene , genetics , gene expression , organic chemistry
A study is reported in which an in situ hybridization technique for the demonstration of human papillomavirus (HPV) employing a biotin–streptavidin polyalkaline phosphatase complex has been successfully applied to formalin‐fixed paraffin‐processed tissue obtained from ten patients with juvenile laryngeal papillomatosis. In all cases, positive results were obtained for either HPV type 6 or 11. Normal vocal cord epithelium was negative.