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DMSO potentiates aminonucleoside of puromycin nephrosis in rats
Author(s) -
Spear Gerald S.,
Nguyen Diep,
Conklin Suzanne,
Wikle John S.,
Fan Joseph,
Lan Yuhuan,
Allen James,
Reineck Scott
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711530212
Subject(s) - nephrosis , puromycin , proteinuria , chemistry , endocrinology , medicine , intraperitoneal injection , body weight , nephrotic syndrome , pharmacology , kidney , biochemistry , protein biosynthesis
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague‐Dawley rats. The effect was evident at 4 as well as 8–9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.