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The immunohistology of Hodgkin's disease—Reed–Sternberg cells and their variants
Author(s) -
Angel Carole A.,
Warford Anthony,
Campbell Andrew C.,
Pringle James H.,
Lauder Ian
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711530104
Subject(s) - reed–sternberg cell , pathology , disease , biology , medicine , lymphoma , hodgkin lymphoma
Thirty‐three cases of Hodgkin's disease were analysed by immunoalkaline phosphatase and immunoperoxidase techniques, using a monoclonal antibody panel, including markers of B‐cells, T‐cells, macrophages, granulocytes, and the antibody Ki‐1. Hodgkin's cells were found to express markers generally regarded as T‐cell, B‐cell, myeloid, or monocyte associated. Furthermore, heterogeneity of marker expression was also seen within the Hodgkin's cell population in any single case. Morphological and immunohistological analogies between cells involved in antigen presentation and Hodgkin's cells are described, suggesting possible relationships between these cell types. Anti‐Leu M 1 was not found to be a particularly sensitive marker of Hodgkin's disease under the conditions used in this study.