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Pleural mesothelioma of epithelial type and pulmonary adenocarcinoma: An ultrastructural and cytochemical comparison
Author(s) -
Dewar A.,
Valente M.,
Ring N. P.,
Corrin B.
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711520409
Subject(s) - carcinoembryonic antigen , pathology , immunoperoxidase , basement membrane , mucin , staining , mesothelioma , periodic acid–schiff stain , adenocarcinoma , ultrastructure , chemistry , biology , medicine , antibody , cancer , immunology , monoclonal antibody
Twelve diffuse pleural mesotheliomas of epithelial type have been compared with 20 intrapulmonary adenocarcinomas. All mesotheliomas were negative for epithelial mucin by diastase periodic acid Schiff staining and for carcinoembryonic antigen by immunoperoxidase staining, whereas 17/20 carcinomas stained for epithelial mucin and 15/20 for carcinoembryonic antigen. Hyaluronidase‐sensitive alcian blue positive material was present in 6/10 mesotheliomas and 0/20 carcinomas. Previously described electron microscopic differences were validated, including one which has so far received insufficient emphasis: microvilli making direct contact through basement membrane deficiences with collagen fibres on the abluminal side of tumour cells were identified in 10/12 mesotheliomas and in 0/20 carcinomas.