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Gastric dysplasia: A stereological and morphometrical assessment
Author(s) -
Tosi Piero,
Luzi P.,
Baak J. P. A.,
Miracco C.,
Vindigni C.,
Lio R.,
Barbini P.
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711520204
Subject(s) - grading (engineering) , dysplasia , stereology , pathology , biopsy , medicine , radiology , biology , ecology
The grading systems of gastric dysplasia suffer from the lack of criteria that separate the changes with an acceptable reproducibility. Repeatable and objective grading of the lesion can be obtained by morphometrically measuring histological criteria normally employed in qualitative grading. In 54 consecutive antrum biopsy specimens in which a blind, independent agreement on the grade of dysplasia had been reached between four independent pathologists, stereological and nuclear morphometrical features have been studied. Single variate, bivariate and multivariate analyses have been performed. Architectural parameters, such as volume and surface densities of glands and epithelium, are especially good discriminators both between mild and moderate, and between moderate and severe dysplasia. Features describing arrangement and shape of nuclei, and nucleolar size are of additional help in improving the objective distinction between moderate and severe dysplasia.