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Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas
Author(s) -
Quirke Philip,
Dixon Michael F.,
Clayden Andrew D.,
Durdey Paul,
Dyson John E. D.,
Williams Norman S.,
Bird Colin C.
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711510408
Subject(s) - aneuploidy , pathological , adenocarcinoma , cell growth , stage (stratigraphy) , cell , biology , pathology , colorectal cancer , medicine , oncology , cancer research , gastroenterology , cancer , genetics , gene , chromosome , paleontology
DNA content and cell proliferation were studied retrospectively in 125 patients presenting from 1974–1981 with rectal adenocarcinoma. The presence of DNA aneuploidy or a high level of cell proliferation were associated with a poor prognosis and when combined were the best predictor of survival after Dukes's stage excluding all other pathological assessments investigated. High cell turnover was significantly associated with an infiltrative pattern of growth, an observation that might explain the poorer prognosis of this pattern in rectal adenocarcinomas.