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Lesions of the renal papilla induced by paracetamol
Author(s) -
Henry M. A.,
Tange J. D.
Publication year - 1987
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711510103
Subject(s) - renal papilla , nephrotoxicity , renal papillary necrosis , necrosis , acetaminophen , acute tubular necrosis , aspirin , renal cortex , medicine , major duodenal papilla , kidney , analgesic , nephropathy , pathology , chemistry , endocrinology , pharmacology , diabetes mellitus
The acute nephrotoxic effects of paracetamol in the uninephrectomized homozygous Gunn rat are different from those of aspirin. Both compounds induce renal papillary necrosis but paracetamol produces accumulation of non‐cellular material in the interstitial space, less damage to interstitial cells, more damage to tubular epithelium, and more severe necrosis of proximal convoluted tubules. In both cortex and papilla only a small fraction of the cells at risk are affected. It is concluded that the findings are consistent with a synergistic nephrotoxic effect between the two compounds, but that the lesions are not sufficiently severe for the natural history of analgesic nephropathy to be wholly explicable by such synergism.