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Nuclear DNA content in breast carcinomas with neuroendocrine differentiation
Author(s) -
Nesland Jahn M.,
Pettersen Erik O.,
Fosså Sophie D.,
Høsie Johan,
Johannessen Jan Vincents
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711500306
Subject(s) - pathology , biology , ploidy , carcinoma , nuclear dna , mammary gland , neuroendocrine differentiation , epithelioma , breast carcinoma , aneuploidy , breast cancer , cancer , medicine , chromosome , gene , genetics , prostate cancer , mitochondrial dna
Sixty‐one breast carcinomas (54 infiltrating ductal carcinomas and seven infiltrating lobular carcinomas) were immunostained with anti‐NSE and analysed with respect to nuclear DNA content. Nine of the 23 NSE‐positive breast carcinomas were diploid, five were triploid, six tetraploid and three pentaploid. Twenty‐one of the 38 NSE‐negative tumours were diploid, 10 were triploid, seven tetraploid, and none were pentaploid. Three of the eight histologically grade 1 tumours in the NSE‐positive group were aneuploid, whereas all the six grade I tumours in the NSE‐negative group were diploid. The results show that a proportion of breast carcinomas with neuroendocrine differentiation are aneuploid and that aneuploid tumours that are grade I histologically are found in the NSE‐positive group and not in the NSE‐negative group.