Premium
The occurrence and clinicopathological significance of serotonin immunoreactive cells in large bowel carcinoma
Author(s) -
Arends Jan W.,
Wiggers Theodore,
Verstijnen Kees,
Bosman Fred T.
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711490204
Subject(s) - serotonin , carcinoma , medicine , pathology , oncology , gastroenterology , receptor
We studied the incidence, clinicopathological relevance and prognostic significance of serotonin immunoreactive cells in a clinically well‐documented series of 300 large bowel cancer patients. Serotonin immunoreactive cells were detected in 8 per cent of the carcinomas, occurring either as focal clusters (4.7 per cent) or as occasional single cells (3.3 per cent). Both types frequently displayed presence of mucin and/or immunoreactivity for secretory component as well. In respect of localization, stage of tumour extension and histological grade tumours with serotonin immunoreactivity showed no significant differences in comparison with carcinomas lacking this feature. In terms of survival, however, the tumours with serotonin immunoreactivity demonstrated a more aggressive clinical course in comparison with tumours without these cells. This phenomenon reached borderline statistical significance. It is therefore concluded that the study of serotonin immunoreactivity in large bowel carcinomas enables the identification of a subpopulation of colorectal carcinomas with a relatively poor prognosis.