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Histogenests of acinic cell carcinoma of the major and minor salivary glands. An ultrastructural study
Author(s) -
Chaudhary Anand P.,
Cutler Leslie S.,
Leifer Calvin,
Satchidanand Sateesch,
Labay Gerald,
Yamane George
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711480407
Subject(s) - myoepithelial cell , acinic cell carcinoma , ultrastructure , pathology , biology , salivary gland , cell type , duct (anatomy) , stem cell , cell , microbiology and biotechnology , anatomy , immunohistochemistry , medicine , mucoepidermoid carcinoma , biochemistry
This studydescribes the light microscopic, histochemical and electron‐microscopic findings of 10 acinic cell carcinomas from the major and mior salivery glands. Ultrastructually, four cell types were identified: secretory acinar cells, intercalated duct‐like cells, pluripotential reserve/stem cells and myoepithelial cells. This cellular composition suggests that the tumours are derived from neoplastic proliferation, cytodifferentiation and functionall maturation of pluripotential reserve/stem cells which normally reside at the acinar‐intercalated duct junctions and /or in the intercalated ducts proper of adult salivery glands. This study further supports the concept that different salivery gland tumours recapitulate various developmental stages in the normal embryogenseis of the salivery glands.