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Light and ultrastructural features of lymphoepithelial lesions of the salivary glands in Mikulicz's disease
Author(s) -
Chaudhary Anand P.,
Cutler Leslie S.,
Yamane George M.,
Satchidanand Sateesh,
Labay Gerald,
Sunderraj Mary
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711480308
Subject(s) - myoepithelial cell , pathology , histogenesis , ultrastructure , hyaline , involution (esoterism) , basal lamina , biology , lamina propria , anatomy , electron microscope , squamous metaplasia , metaplasia , epithelium , medicine , immunohistochemistry , neuroscience , consciousness , physics , optics
Abstract This investigation deals with the histogenesis of the so‐called ‘epimyoepithelial islands’ in Mikulicz's disease of the major salivary glands and is based on light and electron microscopic sludy in six patients. The ‘epimyoepithelial islands’ represent collapsed acini prior to their complete involution and disappearance, the intraductal cellular proliferation, stratification and differentiation into luminal and peripheral myoepithelial cells with partial and complete obliteration of their lumina and finally, cord‐like proliferation and formation of nests of residual pluripotential cells showing squamous metaplasia and occasional myoepithelial cell differentiation. A pink, homogenous and hyaline material on light microscopic examination is multilayered and extracellular and is in close association with the basal lamina when viewed with electron microscope.