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Evidence that multinucleate giant cells are examples of mononuclear phagocytic differentiation
Author(s) -
Papadmitriou John M.,
Van Bruggen Ivonne
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711480205
Subject(s) - multinucleate , giant cell , peripheral blood mononuclear cell , biology , microbiology and biotechnology , macrophage , in vitro , biochemistry , genetics
Murine multinucleate giant cells and mononuclear phagocytes were examined with various quantitative cytochemical and autoradiographic techniques. No evidence was found that multinucleate giant cells were metabolically effete, in fact they compared favourably with mononuclear phagocytes. In addition, rat multinucleate giant cells consistently expressed surface Ia antigens and to a lesser degree fibronectin. It is suggested that multinucleate giant cells are a differentiated derivative of the mononuclear phagocytic system.