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Expression of low molecular weight cytokeratin proteins in cervical neoplasia
Author(s) -
Bobrow Lynda G.,
Makin Carol A.,
Law Sharon,
Bodmer Walter F.
Publication year - 1986
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711480203
Subject(s) - cytokeratin , immunoperoxidase , pathology , immunohistochemistry , monoclonal antibody , metaplasia , cervical intraepithelial neoplasia , squamous metaplasia , epithelium , malignant transformation , keratin , intraepithelial neoplasia , antibody , biology , medicine , cervical cancer , immunology , cancer , prostate
CAM 5.2 is a monoclonal antibody which identifies lower molecular weight cytokeratin proteins (50, 43 and 38 kD). It is an antibody which works reliably on formalin‐fixed, paraffin‐embedded tissues. In this study, using CAM 5.2 in the indirect immunoperoxidase method we have examined ectocervical epithelium ranging from normal, through metaplasia and cervical intraepithelial neoplasia to invasive squamous carcinoma. CAM 5.2 is demonstrated to be a useful indicator of changes associated with malignant transformation in the ectocervix.