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Functional and morphological changes in post‐capillary venules in relation to lymphocytic infiltration into BCG‐induced granulomata in rat skin
Author(s) -
Freemont Anthony J.,
Ford William L.
Publication year - 1985
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711470102
Subject(s) - high endothelial venules , infiltration (hvac) , lymphatic system , pathology , lymphocytic infiltration , biology , lymphocyte , blood capillary , immunology , medicine , circulatory system , endocrinology , physics , thermodynamics
Vessels identical to iymph node high endothelial venules (HEV) have been described in sites of non‐lymphoid tissue lymphocyte accumulation. In this study the function of these (HEV‐like) vessels has been investigated in BCG‐induced skin lesions in the rat. By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV‐like vessels have been shown to be the preferred site of migration. The complicated development of the vessels has been studied and an hypothesis advanced to explain their inter‐relationship with tissue and circulating lymphocytes.