Premium
Histogenesis of pancreatic carcinomas: A study based on 248 cases
Author(s) -
Chen Jie,
Baithun Suhail I.,
Ramsay Mary A.
Publication year - 1985
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711460108
Subject(s) - pathology , mucin , histogenesis , hyperplasia , adenosquamous carcinoma , immunohistochemistry , pancreas , ductal carcinoma , carcinoma , medicine , adenocarcinoma , biology , cancer , breast cancer
Primary pancreatic carcinomas were studied histologically and histochemically, to assess the frequency of ductal hyperplasia in tissue adjacent to malignant neoplasms. Hyperplasia was divided into four types: simple, papillary, atypical and ductular, affecting large, medium and small ducts (ductules). All types of hyperplasia were frequently seen in areas adjacent to carcinomas, including ductal, pleomorphic, mucinous, adenosquamous, small and spindle cell and cystadenocarcinomas. In contrast, acinar cell carcinoma and microadenocarcinoma were less frequently associated with ductal hyperplasia. Mucin histochemistry revealed differences in types of mucin between the normal ducts and hyperplastic pancreatic ducts and carcinomas. The former group contained small amounts of sulphated mucin while the latter showed a marked increase in neutral and sialomucins. Our study also suggests that both papillary and atypical hyperplasia are precancerous lesions, supporting an hypothesis of ductal origin of pancreatic carcinomas.