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Amiodarone lung toxicity: A human and experimental study
Author(s) -
CostaJussà F. R.,
Corrin B.,
Jacobs J. M.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711440202
Subject(s) - amiodarone , lung , bronchiolitis , medicine , toxicity , pathology , pulmonary toxicity , histiocytosis , disease , respiratory system , atrial fibrillation
This paper describes the pathology of pulmonary histiocytosis developing in a patient treated with amiodarone, and reports comparable changes in the lungs of rats and mice to which this drug had been administered. Ultrastructural studies indicate that the experimental lung changes are similar to those produced by iprindole and chlorphentermine. The patient also displayed focal necroses and an eosinophilic bronchiolitis: these may represent further effects of amiodarone on the lung.