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Cytoskeletal control of nuclear arrangement in Langhans multinucleate giant cells
Author(s) -
Rigby P. J.,
Papadimitriou J. M.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711430105
Subject(s) - langhans giant cell , multinucleate , cytoskeleton , giant cell , microbiology and biotechnology , biology , chemistry , pathology , cell , medicine , genetics
Examination of the role of the cytoskeleton in macrophage polykarya (multinucleate giant cells) has established that microfilaments and microtubules are interrelated and contractile cytoskeletal components with opposing actions; when critically maintained at equilibrium, they are responsible for maintenance of the highly organized cellular architecture characteristic of Langhans type syncytia. Disruption of the function of these structures by in vitro incubation with cytochalasin B and/or colchicine can result in reversion to a cytoarchitecture which is more typical of the ‘foreign body’ multinucleate giant cell. These observations strongly reinforce previous suggestions that Langhans multinucleate giant cells are special, more highly organized forms than are ‘foreign body’ multinucleate giant cells.