Premium
The localization of aluminium and other elements inbone tissue of a case of renal osteodystrophy with an associated dialysis encephalopathy syndrome
Author(s) -
McClure John,
Smith P. S.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711420407
Subject(s) - osteomalacia , renal osteodystrophy , osteoid , pathology , chemistry , microanalysis , calcification , bone tissue , mineralization (soil science) , osteoporosis , medicine , kidney disease , organic chemistry , nitrogen
Abstract Bone tissue from a patient with chronic renal failure and a dialysis encephalopathy syndrome has been studied by histological and histochemical means, by flame emission spectroscopy and by electron probe X‐ray microanalysis. There was significant renal osteodystrophy manifest as an osteomalacia. Emission spectroscopy showed the presence of iron (Fe), aluminium (Al), silicon (Si), zinc (Zn), strontium (Sr), lead (Pb) and copper (Cu) in the concentration range 100–1000 parts per million (ppm). Electron probe X‐ray microanalysis showed focal concentrations of Fe and Si in the marrow tissue only, whereas Al was localized to the calcification front zones at the junction of osteoid and mineralized tissue of both trabecular and cortical bone. It is concluded that the presence of Al at these sites could interfere with the mineralization process and significantly contribute to the pathogenesis of haemodialysis‐related osteomalacia and that it is unlikely that the other elements detected are significant in this regard.