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Encephalitis in mice with congenital ocular toxoplasmosis
Author(s) -
Graham D. I.,
Hay J.,
Hutchison W. M.,
Siim J. Chr.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711420405
Subject(s) - toxoplasmosis , encephalitis , medicine , congenital toxoplasmosis , virology , pathology , toxoplasma gondii , immunology , antibody , virus
The brains of mice with congenital ocular toxoplasmosis were examined histologically. Toxoplasma tissue cysts and a subacute/chronic meningo‐encephalitis were present in the brains of all infected mice. The findings were very similar to those seen in human congenital toxoplasmosis. The murine model of congenital toxoplasmic encephalitis described in this paper will be valuable in the study of the pathogenesis, natural history and treatment of this condition.