Premium
The effects of hypobaric hypoxia on the corticotroph population of the adenohypophysis of the male rat
Author(s) -
Gosney John R.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711420303
Subject(s) - corticotropic cell , endocrinology , medicine , hypoxia (environmental) , population , hypobaric chamber , adrenocorticotropic hormone , secretion , anterior pituitary , hormone , biology , effects of high altitude on humans , chemistry , oxygen , anatomy , environmental health , organic chemistry
The effect of hypobaric hypoxia on the corticotroph population of the adenohypophysis has been studied in male rats. After 28 days exposure to a barometric pressure of 380 mm Hg, equivalent to an altitude of 5500 m, there was an increase in their number relative to the total cell population. This may reflect a requirement for a sustained increase in the level of adrenocortical secretion in an hypoxic environment. Alternatively, higher levels of ACTH may be required to maintain normal levels of adrenocortical hormone secretion under these conditions.