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Histopathological characterization of the naturally occurring hepatotropic virus infections of nude mice
Author(s) -
Carthew P.
Publication year - 1984
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711420113
Subject(s) - virology , mouse hepatitis virus , virus , histopathology , cytomegalovirus , biology , laboratory mouse , pathogenesis , immunology , pathology , medicine , viral disease , herpesviridae , gene , covid-19 , genetics , infectious disease (medical specialty) , disease
In the last ten years the mutant athymic nude mouse has been used by many researchers as a model for studying pathological conditions in an immunodeficient host. A major problem with such mice is their susceptibility to viral infections indigenous to murine stocks, such as the hepatotropic mouse coronaviruses. In an effort to define the hepatotropic virus diseases indigenous to nude mice this paper details the pathogenesis and associated comparative histopathology of three common strains of mouse hepatitis virus, reovirus 3 and murine cytomegalovirus in the nude mouse.