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Ultrastructural features of carcinomas induced in nude mice by the inoculation of human oesophageal carcinoma cell lines
Author(s) -
Robinson K. M.,
Bux S.
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711400303
Subject(s) - ultrastructure , pathology , carcinoma , nude mouse , biology , in vivo , cytoplasm , organelle , cell culture , cell , in vitro , carcinoma in situ , cancer research , microbiology and biotechnology , medicine , genetics , biochemistry
Abstract Thirty tumours induced in athymic mice by the inoculation of cells of human oesophageal carcinoma lines were examined by light and transmission electron microscopy, as were 24 cell strains derived from the mouse tumours. All tumours were carcinomas and displayed varying numbers of desmosomes and tonofilaments. Cytoplasmic organelles resembled those in human oesophageal carcinomas in vivo and marker structures such as intranuclear particles persisted in cells grown in nude mice and in vitro . As the nude mouse carcinomas displayed similarities both to one another and to human carcinomas in situ , the nude mouse xenograft system may become a useful model for further studies on tumour biology.