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Induction of renal tumours in rats by the administration of 1,2 dimethylhydrazine
Author(s) -
Sunter J. P.,
Senior P. V.
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711400108
Subject(s) - 1,2 dimethylhydrazine , medicine , subcutaneous injection , incidence (geometry) , body weight , dimethylhydrazine , kidney , small intestine , gastroenterology , pathology , urology , physiology , colorectal cancer , cancer , physics , optics
Administration of dimethylhydrazine (DMH) to adult rats by two subcutaneous injections each of 120 mg(base)/kg body weight and spaced 10 days apart resulted in the development of renal tumours in over 90 per cent. of treated animals at 30 weeks after injection. The tumours were frequently bilateral and multiple, and had the structure of the “mesenchymal” tumours which occur in a high incidence following treatment with nitrosamines. The incidence of tumours both in the small intestine and in the colon was lower than that experienced using a weekly DMH treatment schedule.