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Histopathological diagnosis of hydatidiform mole
Author(s) -
Ockleford C. D.,
Reti L. L.,
Calvert J. P.,
Badley R. A.
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711400107
Subject(s) - antiserum , immunofluorescence , pathology , vimentin , trophoblast , microscopy , differential interference contrast microscopy , differential diagnosis , biology , chemistry , immunohistochemistry , medicine , placenta , pregnancy , antibody , fetus , immunology , genetics
Two microscopical methods are described which are useful for the identification of hydatidiform molar trophoblast. The first is an application of Nomarski's differential interference contrast microscopy which allows whole‐mounted villi to be studied by optical sectioning. The second is an application of indirect immunofluorescence microscopy using a specific antiserum directed against the endothelial cell structural protein known as vimentin.